The study also tested whether adverse effects varied across individuals’ characteristics, such as age and body mass index (BMI), gender, and health status. Fatigue and headaches were the most commonly reported systemic side effects, frequently reported within the first 24 hours after vaccination. The most frequently reported local side effects were tenderness and pain around the injection site, occurring most often the day after injection. Systemic side effects (diarrhoea, fatigue, headache, chills, nausea) affected fewer than one in four people, but were more common with AstraZeneca, with at least one symptom reported by 33.7% after the first dose, compared to 13.5% and 22% after the first and second respective dose of Pfizer. At least one symptom was reported by 71.9% of individuals after the first dose of Pfizer, 68.5% after the second dose, and by 58.7% after the first dose of AstraZeneca. They found local side effects (pain, swelling, redness, itching, swollen armpit glands) affected two in three people, and were more common in Pfizer recipients. Researchers had 627,383 people self-report their symptoms on the COVID Symptom Study app between 8 December and 10 March after receiving either their first or second dose of the Pfizer vaccine, or their first dose of AstraZeneca. Now a new observational study from the UK, published in The Lancet, is giving insight into the typical side effects of the AstraZeneca and Pfizer vaccines, in addition to their effectiveness, in a community setting. ![]() Since then, more than one billion doses have been administered worldwide. It has been five months since the first vaccine against COVID-19 was administered to a 90-year-old woman in the UK. People under 55, women and those previously infected with COVID-19 are more likely to report side effects after receiving either vaccine, according to new research.Īmong recipients of the AstraZeneca and Pfizer vaccines, two in three report local side effects and one in four report systemic effects.
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